Orla Brady began her career with Balloonatics Theatre Company, touring productions of Hamlet and Finnegans Wake. She then returned to Dublin to perform at the Gate Theatre where she played Adele in House of Bernarda Alba and Natasha in Three Sisters. After moving to London, she played Kate in Brian Friel's Philadelphia, Here I Come!, which later transferred from the King's Head Theatre to the West End.
She also played one of four main characters in the BBC's drama series Mistresses. Also, she has appeared in RTÉ's Proof, and had roles in films such as Words Upon the Window Pane (1994), The Luzhin Defence (2000), How About You (2007), and 32A (2007).
Commencing in 2009, Brady portrayed Elizabeth Bishop, the wife of Walter Bishop and the mother of Peter Bishop in the Fox television series Fringe. In 2010, she appeared in the TV series The Deep alongside James Nesbitt, wherein she played Catherine. She also starred in the TV series Strike Back as Katie Dartmouth.
From 2017 to 2019, she had a main role in the AMC martial arts drama series Into the Badlands as Lydia. In 2019, Brady portrayed Dr. Hopple in American Horror Story: 1984, the ninth season of the FX horror anthology television series American Horror Story.
In 2020, she had a recurring role as Laris, Jean-Luc Picard's Romulan housekeeper, in the first season of the sci-fi series Star Trek: Picard. In the show's second season, she joined the main cast as Tallinn, a Human "Supervisor".
"Our business is all about collaboration, about finding the right people to work with. The storytellers, the people who will invest in those stories emotionally and financially, and of course the actors who will help bring those stories to life."
Orla Brady